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Optimizing Modified Permanent Magnet Array

Magnetic Drug Targeting (MDT) is a therapeutic method to deliver the drug to a target lesion in response to an external magnetic field. In conventional MDT, the magnetic drug carriers are delivered to the target but some portion of drugs can be delivered to unwanted normal cells. This unwanted delivery can cause side effects to normal cells. In order to minimize this unwanted journey, Focused Magnetic Drug Targeting (FMDT) is proposed and the required magnetic force map for FMDT is modeled. To fulfill the magnetic force map, a modified permanent magnet array (Halbach array) is used and optimized. By simulating magnetic particle trajectory through the Finite Element Method (FEM), the parameters of geometry of the modified Halbach array are optimized and validated experimentally using a fabricated optimized Halbach array. With this optimizing process, FMDT can be achieved in clinical application.

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